Publicly, she says she hasn't decided whether to stay in the leadership or not:
http://www.reuters.com/article/idUSTRE6A305B20101104However, almost everyone is expecting that she'll step down from the leadership and become a backbencher, possibly even resign her seat in Congress early, and force a special election.
She's 70 years old. She'd realistically only remain in the leadership for a couple more terms anyway. I doubt she'd be interested in staying on as Democratic leader in the House unless there was a good chance that she could become Speaker of Dem-majority House again after 2012. But that doesn't look too likely, given the scale of GOP wins this time.