The region has lost 17 seats in 25 years. i'd also be interested in seeing composition without Pennsylvania, which I think skew the Democratic dominance a bit.
It definitely would, especially in the early half of the 20th century (there were elections where all but one or two seats out of 30-something was Republican) and now with its ridiculously gerrymandered map. I'm not going to run through all the numbers again, but doing a few random years it seems to skew it 2-5 points to the right on average.