In addition, no matter who wins the Senate in 2016, the Senate sounds likely to turn into a Republican supermajority in 2018 because many of the incumbent Democratic seats are located in conservative states like Indiana, Missouri, North Dakota and Montana. And in addition, the GOP is likely to target swing states like Florida, Ohio, Michigan, etc. If that's the case, then Hillary Clinton will have a hard time to get her policies done and to run for a second term.
By supermajority you mean 60? That seems pretty unlikely to me that they would flip 11+ seats. Well in any case, I wouldn't say it's likely. It's on the outer edge of what's reasonably possible.