I honestly think the most likely thing to take Trump down at this point is him saying something moderate and sensible with a lot of people watching. People think "Oops!" took down Perry in 2011, but the line that really did him in was "Have a heart!" regarding the children of undocumented immigrants. If, for example, Trump is asked during a debate something about gay rights and he responds "Gay people are Americans too, and they are granted equal protection by our Constitution. Regardless of your personal beliefs, we all must recognize that fundamental right," his numbers will plummet.
I don't think Trump would say that. I think he'd say "I know some gays. Real killers...brilliant negotiators. They can bring clients to all the hottest spots in Manhattan...they know how to close the deal there. It's true! Real sharks. I know a few gay negotiators I want on my team when we sit down with China! They'll go to the hippest show Off-Off-Broadway and settle the trade deficit over tapas and sangria. China won't know what hit 'em."
EDIT: I seriously expect that Trump will respond to the question "do you support same sex marriage" with "Only if they hold the reception in one of my hotels" and that the audience will just roar in approval.
"No one will be better for the gays than Donald Trump."