Easily. How on earth it's important, say, for a man in 7th disitrict of Washington (Seattle) whom Democrats run in 3rd district of Alabama? Or - Mississippi? Or - Louisiana? It's a foolishness to run exactly similar candidates in all places. Alabama's democratic party was ALWAYS substantially more conservative then National one (or Democratic party of Washington state). The same - for other Deep South states. The same, BTW, for Republicans, where, say, Republican party of Vermont or Massachusetts was almost always to the left of national one. The only axiom i have in politics - the party must run candidates, which are suitable for their districts. You adapt candidates (and party) to district and it's people, not vice versa.
Well, politics is more nationalized today than it was a couple of decades ago so the conservative views of a Democratic candidate in Alabama's 3rd district may very well have an effect on how somebody in Washington's 7th perceives the wider party. Why do you think so many fiscal conservatives have abandoned the GOP in areas of the nation that used to be Republican strongholds? Even in congressional races the general position of the party matters today.
What's more, why would a liberal party be interested in swelling its ranks with cultural conservatives for the sole purpose of getting past 218? The main goal of most voters is to see policies they care about enacted. A cultural liberal from Seattle isn't going to see that happen if the Democratic caucus is full of white Southerners.