I was offended by his recent remark "Mississippi gets more than their fair share back in federal money, but who the hell wants to live in Mississippi?" and then refusal to make an apology for it. Pretty much every Mississippian I know that knows about Rangel hates him because of this, no matter what their political leaning is.
Why let such a dumb throw-away comment like that make you hate him?
Here's the reality of it: people up north make fun of Mississippi. No one really defends the Deep South. It's not any more personal/accurate than the jokes about West Virginia are.
(To be fair, though, you do rank 50th-51st in almost everything.
So it's not like the state doesn't represent some not-so-great things.)