Sure it'll be an issue with some black voters.
But overall it'll help her. A lot of the resentment against Democratic women is that they are seen as not being under the ownership of white men; particularly if those women are white. It is seen that these women should be the cheerleading brigade for white men, but aren't as they've joined the party of minorities. As a woman of color, white men have less of an ownership feeling towards Harris to begin with; being married to a white man only makes her even less threatening. In some ways she's the perfect Democratic woman to assuage white men's anxieties.