I'm thinking maybe Hillary Clinton/Mark Warner. If not Clinton, then Joe Biden/Kirsten Gillibrand.
As for the Rs, I'm thinking Scott Walker/Cathy McMorris Rodgers. I just have a gut feeling that McMorris Rodgers wants to be higher up than House Leadership, and there's no chance she'll run for Senate or Governor here in Washington. I'm also not sure how the Rs feel about having a House member as VP nominee again, but I'm sticking with that prediction.
Ryan did better than most people realize... that loss was split between Romney and the GOP's various Senate candidates