Could this be the beginning of the end?
As has been demonstrated time and time again, the answer to that question is always "no." People really ought to stop asking it.
National polling trends put "the beginning of Trump's end" back sometime around the start of March. It doesn't really matter how the R nomination contest goes for him if he can't turn that around. (And no, I don't think he can.)
If it is really "the end" for Trump it will occur in the general election, not in the Republican primaries.