--see above--
Personally, I voted "Who knows?" I think it's extremely unlikely, but any theory about the fundamental nature of the universe is nonfalsifiable—that is, impossible to conclusively disprove.
I voted No. Simulation of what? Reality? Then what is reality? We get into a "who created G-d"-style infinite regression.
Some physicists have found possible evidence that the universe is holographic, that we might just be some advanced being's computer game.
I put "who knows?" I don't think so, but really, there's no way to test this and know for sure, at least right now.