1. The rise of a religious left, which allows Democrats to seriously contest the Evangelical vote, forcing the GOP to expand its coalition and making the Deep South competitive again. A Great Awakening style revival historically follows the kind of economic turmoil the country has recently faced, and the movement would probably have a progressive bent given today's youth.
The "religious left" of which you speak is also fervently anti-abortion. The Democrats can have them or they can have the feminists. They can't have both.