What federal measure? No federal measure pertaining to slavery or abortion would be constitutional, and none was attempted until after the Civil War.
But fear of them is what ultimately led to the seperation, wasn't it?
I would disagree with that assessment. Most of the battle was about the spread of slavery into the territories. Lincoln himself made it very clear he had no intention to interfere with slavery in the South, and even endorsed a constitutional amendment that would prohibit any future amendment giving the Congress the power to interfere with the domestic institutions of any state.