Disagree. If John Kerry and John Edwards couldn't win Arkansas, Iowa and Missouri...how the hell will HILLARY CLINTON?
Last time I checked John Edwards was never at the top of the ticket. If you're referring to Kerry and Edwards as a single ticket all I have to say is: Massachusetts Liberal. Even if Kerry had run with a Republican running mate there would be no way for him to win any southern states. Also, looking at 2004 results won't be helpful in predicting 2008 unless Democrats go with another super Liberal.
In 1996 Clinton won majorities, not pluralities but majorities, in Iowa and Arkansas (and Louisiana too actually but Katrina killed the Democrat's chances there). If the Clintons are still as popular in AR as I have heard then she should be highly competitive there. Also, remember that this is a state with 2 Democratic Senators and 3 out of 4 Democratic Representatives. Out of all the South it is one of the best chances the Democrats have. Missouri might be a stretch but even without it Hillary still wins comfortabley on my map.