Wishful thinking, but this is mainly for primary purposes:
Eliot Spitzer or Carolyn Maloney to knock off Hilary Clinton (NY)
Rosa DeLauro to defeat Joe Lieberman (CT)
Pete Stark to defeat Dianne Feinstein (CA)
I live in CT and we never hear anything from DeLauro, she's very quiet. The only House Member who ever does anything is Chris Shays-R-4, and I like him b/c he is an outspoken opponent of the Southern wing of his own party.
I wouldn't mind seeing Lieberman replaced but the Dump Joe rumors exist only on the Internet, there's no backing for it in this state.
I don't know where all the hate towards Bob Byrd is coming from. It was 60 years ago, give it a friggin rest.
Now that Zell Miller is gone, I honestly can't think of any Dems I'd like to see replaced, besides Lieberman.